Quantitation of the interaction level between the active principle and each one of the excipients allow us to improve product stability, bioavailability and shelf life.
All components of a pharmaceutical product and mixtures of the active component API, and each one of the excipients are analyzed using calorimetry, by Differential Scanning Calorimetry. All of this information is used to identify which components modify physically and chemically the active component. The interaction strength between the active component and each one of the excipients are quantitated and the proportion of each excipient is optimized for the final product, enhancing shelf life.
For this pharmaceutical form it is determined the best composition for bioavailability and shelf life design requirements, and also if the tablet should have one layer or more for the formula under consideration. Furthermore, it is resolved if the enteric cover is compatible or not with the tablet.
For this pharmaceutical form the best composition for bioavailability and shelf life design requirements is determined. Furthermore, the compatibility between the final formula and the proposed capsule is resolved.
For these pharmaceutical forms, compatibility between the active component and all liquid excipients are measured. Formula composition is optimized, so as that active component decomposition is minimized, to guaranty that product bioavailability and shelf life are within design requirements.
For these pharmaceutical forms, compatibility between the active component and all liquid excipients are measured. Formula composition is optimized, so as that active component decomposition is minimized, to guaranty that product bioavailability and shelf life are within design requirements.